药合制药六章环合.pdf

Unit5Cyclization环合

5.1概述

环合是指通过碳碳键和/或碳杂(氮、

氧、硫等)键的形成，使开环化合物转

化为环状化合物的一类反应。

Atorvastatinwasfirstsynthesizedin1985byBruceRoth

whileworkingatParke-DavisWarner-Lambert(now

Pfizer).With2009salesofUS$12.3billion,Lipitorwasthetop-

sellingbrandedpharmaceuticalintheworld.USpatentprotection

isscheduledtoexpireinJune2011.However,Pfizermadean

agreementwithRanbaxyLaboratoriestodelaythegenericlaunch

intheUSuntilNovember2011.

FormulaMol.mass