Leteprinim-AIT-082-free-acid-DataSheet-生命科学试剂-MCE.pdf

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Inhibitors•ScreeningLibraries•Proteins

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Leteprinim

Cat.No.:HY-120251

CASNo.:138117-50-7

Synonyms:AIT-082freeacid

分⼦式:C₁₅H₁₃N₅O₄

分⼦量:327.29

作⽤靶点:ReactiveOxygenSpecies

作⽤通路:Immunology/Inflammation;MetabolicEnzyme/Protease;NF-κB

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Leteprinim(AIT-082freeacid)，⼀种嘌呤类似物，是⼀种神经保护剂和认知增强剂。Leteprinim是⼀种神经

营养性因⼦。Leteprinim能诱导脊髓损伤后脑源性神经营养因⼦(BDNF)mRNA的产⽣，和在基底前脑中神经

⽣长因⼦(NGF)mRNA的产⽣。Leteprinim降低培养的海马体神经元中⾕氨酸毒性。Leteprinim还能增加⾎

红素加氧酶1/2mRNA⽔平，在细胞抗活性氧(ROS)中发挥作⽤。

体外研究Leteprinim(5–50ng/mL,24and48h)enhancesneurotransmitterrelease,increasessecretionof

synaptophysininPC12cells[2].

体内研究Leteprinim(30or60mg/kg,i.p.,for7days)protectratsagainstKainate(12mg/kg)inducedexcitotoxicityof

hippocampalneurons[1].

Leteprinim(60mg/kg,i.p.)enhancesworkingmemoryinyoungandagedmice[3].

Leteprinim(60mg/kg;i.p.;singledosage)significantlyreducesthenumberofapoptoticneuronsinhypoxic-

ischemicbraininjuryratpups[4].

AnimalModel:Wistarratpups(hypoxic-ischemicbraini