依维莫司为晚期乳腺癌治疗.ppt

下载文档

0
0
约3.29万字
约 35页
2024-05-10 发布于广东
举报
版权申诉
保障服务

依维莫司为晚期乳腺癌治疗.ppt

1、本文档共35页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。

*Theincreaseinthefrequencyofsomeadverseeventsdidnottranslateintodifferencesinqualityoflife**Boneturnovermarkersarepeptidefragmentsreleasedasbyproductsofboneremodelingorenzymesinvolvedinboneturnover,andmayreflectongoingratesofboneresorption(eg,C-telopeptideoftypeIcollagen[CTX])orformation(eg,bone-specificalkalinephosphatase[BSAP],amino-terminalpropeptideoftypeIcollagen[P1NP]).Thebargraphrepresentsthepercentagechangeinbonemarkerlevelsfrombaseline.Barsthatextendbelowthex-axisrepresentbonemarkerlevelsthatdecreasedrelativetobaselinelevels.Conversely,barsthatextendabovethex-axisshowbonemarkerlevelsthatincreasedrelativetobaseline.Changesinbonemarkerlevelsrelativetobaselinereflectincreasedratesofboneturnover(resorptionandformation).AllAIshavebeenshowntoincreaseboneturnoverduringadjuvanttherapy,asassessedbylevelsofboneresorptionandformationmarkers.IntheTEAMtrial,EXEtreatmentwasassociatedwithelevatedlevelsofCTXandP1NPwithin3months,andtheincreasesweresustainedforupto12(P1NP)or24(CTX)months.1TheIntergroupExemestaneStudyalsoshowedelevatedlevelsofboneresorptionmarkersfortheentiredurationofEXEtreatment.2AlthoughtheeffectsofEVEaloneonboneturnovermarkersareyettobeelucidatedinhumans,preclinicaldatashowthatmTORinhibitionwithrapamycincanreduceTRAPactivity(ameasureofosteoclast-mediatedboneresorption).3IntheseanalysesfromBOLERO-2,theadditionofEVEtoEXEappearstomarkedlyreduceEXE’seffectonboneturnoverlevels.References:1.HadjiP,etal.ESMO2010.Abstract1185.2.ColemanRE,etal.BCRT.2010;124(1):153-161.3.GlantschnigH,etal.CellDeathDiffer.2003;10(10):1165-1177.**Themostcommongrade3and4AEswerestomatitis,anemia,dyspnea,hyperglycemia,fatigue,andpneumonitis.ThesideeffectsobservedintheBOLERO-2t