2024肺癌ASCO最新进展之Lorlatinib vs Crizotinib in Treatment-NaivePatients With Advanced ALK+ Non-SmallCell Lung Cancer 5-Year Progression-FreeSurvival and Safety From the CRoWN Study.pdf
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LorlatinibvsCrizotinibinTreatment-NaivePatientsWithAdvancedALK+Non-SmallCellLungCancer:5-YearProgression-FreeSurvivalandSafetyFromtheCROWNStudy
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KeyTakeaways
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CROWN:ARandomizedGlobalPhase3Study
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CurrentPostHocAnalysesat5Years
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At60.2MonthsofMedianFollow-Up,MedianPFSbyInvestigatorWasStillNotReachedWithLorlatinib
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PFSBenefitWithLorlatinibWasObservedAcrossPatientSubgroups
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LorlatinibShowedSuperiorPFSBenefitIrrespectiveofPresenceorAbsenceofBaselineBrainMetastases
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TimetoICProgressionbyInvestigatorAssessmentWasLongerWithLorlatinib(ITTPopulation)
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TimetoICProgressionWasLongerWithLorlatinibinPresenceorAbsenceofBaselineBrainMetastases
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