case-controla dietary pattern protective against type 2 diabetes epic病例对照研究一种预防型糖尿病饮食模式.pdfVIP

Diabetologia(2005)48:1126–1134

DOI10.1007/s00125-005-1743-1

ARTICLE

C.Heidemann.K.Hoffmann.J.Spranger.

K.Klipstein-Grobusch.M.Möhlig.A.F.H.Pfeiffer.

H.

Adietarypatternprotectiveagainsttype2diabetes

intheEuropeanProspectiveInvestigationintoCancer

andNutrition(EPIC)—PotsdamStudycohort

Received:12August2004/Accepted:28January2005/Publishedonline:12May2005

#-Verlag2005

Aims/hypothesis:Theaimofthisstudywasto0.26and0.27,respectively(p=0.0006fortrend).Conclu-

identifyadietarypatternassociatedwithdiabetes-relatedsions/interpretation:Ahighscorefortheidentifieddie-

biomarkersandtoinvestigatewhetherthispatternisasso-tarypatternisassociatedwithamorefavourablebiomarker

ciatedwiththeincidenceoftype2diabetes.Methods:Aprofileandasubstantiallyreducedincidenceoftype2

nestedcasecontrolstudyof192casesoftype2diabetes.

diabetesand382controlsubjectsmatchedforandage

wasconducted.Allsubjectswereparticipantsinthepopu-KeywordsAdiponectin.Biomarker.C-reactiveprotein.

lation-basedEuropeanProspectiveInvestigationintoCan-Dietarypattern.EPIC.Epidemiology.HbA1c.HDL

cerandNutrition(EPIC)PotsdamStudy.Dietarypatterncholesterol.Type2diabetes

AbbreviationsCRP:C-reactiveprotein.EPIC:European

lesterol,C-reactiveproteinandadiponectinasresponseProspectiveInvestigationintoCancerandNutrition.OR:

variablesinreducedrankregression.Theassociationofoddsratio.RRR:reducedrankregression

thescorewithdiabetesriskwasestimatedbyconditional

logisticregressionanalysis.Results:Ahighscoreforthe

identi