随机临床试验诊断初步治疗中基于gerdq算法与内窥镜检查方法之间比较1 jonasson.pdfVIP

AlimentaryPharmacologyandTherapeutics

Randomisedclinicaltrial:acomparisonbetweena

GerdQ-basedalgorithmandanendoscopy-basedapproach

forthediagnosisandinitialtreatmentofGERD

†‡§

C.Jonasson*,B.Moum,C.Bang,K.R.AndersenJ.G.Hatlebakk*

*UniversityofBergen,InstituteofSUMMARY

Medicine,Bergen,Norway.

†OsloUniversityHospital,Instituteof

ClinicalMedicine,Oslo,Norway.Background

‡SpesialistgruppenGastro,Nesttun,Thediagnosisofgastro-oesophagealrefluxdisease(GERD)remains

Norway.challenging.Analgorithm,facilitatedbyaquestionnaire,mayprovidea

§DepartmentofHealthSciences,morestructuredandcost-effectivecareofpatients.

UniversityofOslo,Oslo,Norway.

Aim

Correspondenceto:TocomparesymptomcontrolachievedwithempiricaltherapyforGERD,

DrC.Jonasson,InstituteofMedicine,inanalgorithmbasedontheGerdQ(newstructuredpathway,NSP),with

UniversityofBergen,P.O.box7804,thatofcurrentcareafterendoscopy(ordinaryclinicalpathway,OCP).

NO-5021Bergen,Norway.

E-mail:christian.jonasson@med.uib.no

Methods

PatientswithsymptomsofGERD,butwithoutalarmfeatures,wererandomised

Publicationdatainanopen,parallel-groupstudyandfollowedfor4–8weeks.IntheNSP,GerdQ

Submitted2March2012scorewasusedasabasisforbothdiagnosisandatreatmentalgorithm.Patients

Firstdecision14March2012

Resubmitted22March2012withhighlikelihoodofGERDweretreatedempiricallywithaPPIwher