固有免疫研究进展【141页】.pptxVIP

;Contents;InnateImmunitySystem

一、固有免疫系统;宿主固有免疫系统;（一）固有屏障结构;Figure2-4;Barriersofinnateimmunitysystem;Localbarrierstructure;（二）固有免疫细胞;ComponentsoftheImmuneSystem;固有免疫细胞;Phagocytosis;吞噬和杀菌过程：

趋化?黏附?吞入?杀灭与消化;Real-timemovieofphagocytosis;（三）固有免疫分子;固有免疫分子;固有免疫分子;Lysozyme;Cytokines;InnateRecognition

二、固有免疫识别;FatherofInnateImmunity：Prof.JanewayC;（一）识别什么？PAMPs;PAMPandPRR;29;Pathogen-AssociatedMolecularPatterns(PAMPs);黏附素（adhesin);fimbrialadhesins(E.coli);LigandSpecificitiesofTLRs;（二）用什么去识别？PRR;36;37;38;Toll-likeReceptors(TLRs);TLRsignaling;43;TLRsininnateandadaptiveimmunity;TLRscontroladaptiveimmunity;参与固有免疫识别的受体

模式识别受体（PRR);抗感染免疫与固有免疫识别;NOD-likereceptors,NLR;NLRsubfamilies;52;53;FunctionsofNLR;55;NLRandinflammasome;IL-1β/IL-18inflammosome;NALP3andIPAFinflammasome;RIG-Ilikereceptors，RLR;60;61;e.g.,HCVproteinNS3/4AeliminatesantiviralsignalingbycleavageofMAVSandTRIF.?;63;InnateImmuneResponse

固有免疫应答;69;视频

(ImmuneResponse);Intracellularkillingmechanisms;ProgressofInnateImmunity

固有免疫研究进展;抗细菌感染免疫的

固有免疫识别与免疫应答;抗病毒免疫的

固有免疫识别与免疫应答;;;;免疫病理损害机制;热 红 肿 痛功能丧失;Bacteria;AnimalmodelofP.aeruginosainfection;;Type-1(Red)vs.Type-2(Green);GeneexpressiondifferencesconfirmedbyPCR

;RNAexpressionofcellulargenesup-(ordown-)regulated4-foldorhigherinbothmousestrains;TLR4inbacterialkeratitis;Dayspostinfection;;Dayspostinfection;Pro-inflammatorycytokineproduction;Dayspostinfection;;;;;TLR9-siRNAinhibitsmRNAexpressioninvitro;TLR9silencinginvitro

(Rho-CpGasareadout);TLR9SilencingInVivo;ConfirmingSilencingWorksInvivo;;;科研课题：固有免疫识别与免疫应答;NegativeregulationofTLRsignaling;NegativeregulationofTLR4signaling;SIGIRRandST2:

MembersofimmunoglobulindomainsubgroupofTLR/IL-1Rsuper-family

NegativelyregulateTLRsignaling

Ligandunknown(SIGIRR)

LigandforST2(IL-33);TLR负调控：抑制过度炎症反应;RoleofSIGIRRinresistanceagainstP.aeruginosakeratitis;Bacteria;