卵巢上皮性肿瘤中claudin3、claudin4的表达及其意义 .pdfVIP

卵巢上皮性肿瘤中claudin3、claudin4的表达及其意义

李传应;葛霞

【摘要】目的探讨claudin3、4与卵巢癌的发生、发展关系.方法使用免疫组化

及原位杂交方法检测卵巢上皮、浆液性及黏液性囊腺瘤、交界性囊腺瘤、原发性卵

巢癌、浆液性囊腺癌的远处转移灶及卵巢转移性癌的石蜡包埋组织中claudin3、4

蛋白及claudin4-mRNA的表达情况.结果claudin3、4蛋白及claudin4-mRNA

在卵巢癌中表达强于交界性肿瘤,交界性肿瘤强于良性肿瘤,但是交界性浆液性肿瘤

和良性肿瘤表达无明显差异;在卵巢癌的转移灶中表达程度类似于原发灶;在转移至

卵巢的癌中的表达明显弱于卵巢原发癌.结论claudin3、4表达增强与原发性卵巢

癌的发生、发展、转移密切相关;浆液性囊腺癌可以有良性肿瘤直接恶变,也可以由

交界性肿瘤发展而来,但不经历良性-交界性转变过程;黏液性囊腺癌则不仅可以由良

性肿瘤直接恶变,也可以经历良性-交界性-恶性发展过程.%ObjectiveToexplore

theeffectsofclaudin3,4ongenesisanddevelopmentofovary

cancinoma.MethodsImmunohisto-chemicalandInsitu

hybridization(ISH)methodswereemployedtodetecttheexpressionof

claudin3,4proteinsandclaudin4-Mrnainnormalepithelium,benign

cystadenoma,cystadenomaofborderline,allkindsofovary

carcinoma,metastasisofserouscystadenocarcino-ma,metastaticcarcinoma

toovary.ResultsClaudin3,4proteinandMrnahardlyexpressedinnormal

ovarianepitheliumandepithelialtumorofbenign,andwereobviously

weakerthanintumorofborderline,buttherewerenodistinctionbetween

borderlineseroustumorandseroustumor.Theexpressionofclaudin3,4in

borderlinetumorswereobviouslyweakerthaninallkindsofovarian

carcinoma.Theexpressioninmetastasiswassimilartothatatovarian.The

expressioninmetastasisatovaryofothertumorwasobviouslyweaker

thaninovariancarcinoma.ConclusionTheenhancementofexpressionof

claudin3,4arecloselycorrelatedwiththegenesis,developmentand

metastasisofovariancarcinoma.Serouscarcinomacantransformfrom

benigntumororfromserousborderlinetumor,butbenigntumorcant

transformtoborderlinetumor.Theovarianmucinouscarcinomacan

transformfrombenignandborderlinetumor,orchangefrombenignto

borderlinethentocarcinoma.

【期刊名称】《安徽医药》

【年(卷),期】2012(016)003

【总页数】3页(P342-344)

【关键词】claudin3、4;交界性肿瘤;原位杂交

【作者】李传应;葛霞

【作者单位】安徽省立医院病理科,安徽合肥230001;蚌埠医学院病理学教研室,安

徽蚌埠233000

【正文语种】中文

卵巢癌占女