Ceramide-3-d3-N-Stearoyl-phytosphingosine-d-sub-3-sub-生命科学试剂-MCE.pdf

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Ceramide3-d3

Cat.No.:HY-141582S

CASNo.:1354806-91-9

Synonyms:N-Stearoylphytosphingosine-d3

分⼦式:C₃₆H₇₀D₃NO₄

分⼦量:586.99

作⽤靶点:Isotope-LabeledCompounds;BiochemicalAssayReagents

作⽤通路:Others

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Ceramide3-d3(N-Stearoylphytosphingosine-d3)是氘代标记的Ceramide3。C18Phytoceramide

(t18:0/18:0)(Cer(t18:0/18:0))是⼀种⽣物活性鞘脂，存在于酿酒酵母、⼩麦籽粒和哺乳动物表⽪的⾓质层中。

Cer(t18:0/18:0)由植物鞘氨醇主链胺连接到C18脂肪酸链组成。Cer(t18:0/18:0)具有调节细胞凋亡、细胞分

化、平滑肌细胞增殖和抑制线粒体呼吸链的作⽤。它还抑制组蛋⽩刺激的⼩⿏⽪肤组织中过敏性细胞因⼦IL-

4、TNF-α以及转录因⼦c-Jun和NF-κB的表达。含有cer(t18:0/18:0)的配⽅已被⽤作化妆品中的⽪肤保护

剂，因为它们可以减少⽔分流失，防⽌表⽪脱⽔和刺激。

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019

Feb;53(2):211-216.

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