N1-Acetyl-5-methoxykynuramine-hydrochloride-AMK-hydrochloride-生命科学试剂-MCE.pdf

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Inhibitors•ScreeningLibraries•Proteins

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N1-Acetyl-5-methoxykynuraminehydrochloride

Cat.No.:HY-W587743

CASNo.:1215711-91-3

Synonyms:AMKhydrochloride

分⼦式:C₁₂H₁₇ClN₂O₃

分⼦量:272.73

作⽤靶点:ProstaglandinReceptor;PGEsynthase;COX;Reactive

OxygenSpecies

作⽤通路:GPCR/GProtein;Immunology/Inflammation;Metabolic

Enzyme/Protease;NF-κB

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性N1-Acetyl-5-methoxykynuramine(AMK)hydrochloride是神经激素褪⿊素(HY-B0075)的活性代谢产物。N1-

Acetyl-5-methoxykynuraminehydrochloride(200µM)能有效清除单线态氧(ROS)。1N1-Acetyl-5-

methoxykynuraminehydrochloride还能在浓度和时间依赖的⽅式下，抑制肾上腺素和花⽣四烯酸诱导的前

列腺素E2(PGE2)和前列腺素D2(PGD2)产⽣，并在500µM浓度下在RAW264.7巨噬细胞中抑制LPS(HY-

D1056)诱导的COX-2⽔平的增加。在MPTP(HY-15608)诱导的帕⾦森病⼩⿏模型中，N1-Acetyl-5-

methoxykynuraminehydrochloride(20mg/kg)能够减少⿊质和纹状体中细胞质和线粒体的脂质过氧化的增

加。N1-Acetyl-5-methoxykynuraminehydrochloride可⽤于代谢和神经疾病研究[1][2][3][4][5][6]。

IC50TargetCOX-2

REFERENCES

[1].HirataF,etal.Invitroandinvivoformationoftwonewmetabolitesofmelatonin.JBiolChem.1974Feb25;249(4):1311-3.

[2].SchaeferM,etal.ThemelatoninmetaboliteN-acetyl-5-methoxykynuramineisapoten