Z-Rilpivirine-Z-R278474-生命科学试剂-MCE.pdfVIP

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(Z)-Rilpivirine

Cat.No.:HY-167642

CASNo.:500287-94-5

Synonyms:(Z)-R278474;(Z)-TMC278;(Z)-DB08864

分⼦式:C₂₂H₁₈N₆

分⼦量:366.42

作⽤靶点:DrugIsomer;HIV;ReverseTranscriptase

作⽤通路:Others;Anti-infection

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性(Z)-Rilpivirine((Z)-R278474)是Rilpivirine(HY-10574)的(Z)-异构体。Rilpivirine是⼀种有效和特异性的⼆芳

基嘧啶(DAPY)⾮核苷逆转录酶抑制剂(NNRTI)。Rilpivirine对野⽣型HIV(EC50=0.4nM)和突变体(EC50=0.1-

2.0nM)具有很⾼的抗病毒活性[1]。

REFERENCES

[1].ReillySW,etal.Late-StageCarbonIsotopeExchangeofArylNitrilesthroughNi-CatalyzedC-CNBondActivation.JAmChemSoc.

2021Mar31;143(12):4817-4823.

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