4-P-PDOT-Standard-生命科学试剂-MCE.pdf

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4-P-PDOT(Standard)

Cat.No.:HY-100609R

CASNo.:134865-74-0

分⼦式:C₁₉H₂₁NO

分⼦量:279.38

作⽤靶点:MelatoninReceptor

作⽤通路:GPCR/GProtein;NeuronalSignaling

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性4-P-PDOT(Standard)是4-P-PDOT的分析标准品。本产品⽤于研究及分析应⽤。4-P-PDOT是⼀种有效的，选

择性的和亲和性的褪⿊激素受体(MT2)拮抗剂。4-P-PDOT对MT2的选择性是MT1的300倍以上。4-P-PDOT

可显着抵消褪⿊激素介导的抗氧化作⽤(GSH/GSSG⽐，ERK磷酸化，Nrf2核易位，Nrf2DNA结合活性)。

IC50TargetMT2receptor[1]

REFERENCES

[1].DubocovichML.Melatoninreceptors:aretheremultiplesubtypes?TrendsPharmacolSci.1995Feb;16(2):50-6.

[2].hinEJ,etal.MelatoninattenuatesmemoryimpairmentinducedbyKlothogenedeficiencyviainteractivesignalingbetweenMT2

receptor,ERK,andNrf2-relatedantioxidantpotential.IntJNeuropsychopharmacol.2014Dec30;18(6).pii:pyu105.

[3].ChristopherBrowning,etal.Pharmacologicalcharacterizationofhumanrecombinantmelatoninmt1andMT2receptors.BritishJournal

ofPharmacology(2000)129,877-886.