LY294002-hydrochloride-Standard-生命科学试剂-MCE.pdf

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Inhibitors•ScreeningLibraries•Proteins

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LY294002hydrochloride(Standard)

Cat.No.:HY-10108AR

CASNo.:934389-88-5

分⼦式:C₁₉H₁₈ClNO₃

分⼦量:343.8

作⽤靶点:PI3K;CaseinKinase;DNA-PK;Apoptosis

作⽤通路:PI3K/Akt/mTOR;CellCycle/DNADamage;StemCell/Wnt;

Apoptosis

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性LY294002(hydrochloride)(Standard)是LY294002(hydrochloride)的分析标准品。本产品⽤于研究及分析应

⽤。LY294002hydrochloride是⼀种有效的⼴谱PI3K抑制剂，对P110α,P110δ和P110β的IC50分别为

0.5,0.57和0.97μM。IC50值分别为P110α、P110δ和P110β的0.5、0.57和0.97μM。LY294002

hydrochloride也能抑制CK2，其IC50为98nM。LY294002hydrochloride可⽤于胰腺癌研究[1][2][3]。

IC50TargetIC50:0.098μM(CK2),0.5μM(p110α),0.57μM(p110δ),and0.97μM(p110β),3.869μM(CK2α2)[1][2]

REFERENCES

[1].BaiR,etal.TheeffectofPI3KinhibitorLY294002andgemcitabinehydrochloridecombinedwithionizingradiationontheformationof

vasculogenicmimicryofPanc-1cellsinvitroandinvivo.Neoplasma.2016;63(1):