EGFR-IN-146-生命科学试剂-MCE.pdf

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EGFR-IN-146

Cat.No.:HY-169566

CASNo.:166039-38-9

分⼦式:C₂₀H₁₆N₄

分⼦量:312.37

作⽤靶点:EGFR;AMPK

作⽤通路:JAK/STATSignaling;ProteinTyrosineKinase/RTK;

Epigenetics;PI3K/Akt/mTOR

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性EGFR-IN-146是⼀种EGFR抑制剂，能够抑制EGFR信号通路，通过激活AMPK途径，改善胰岛素敏感性，可

有效降低⾎糖⽔平和体重。EGFR-IN-146在研究糖尿病和肥胖症中有巨⼤潜⼒[1]。

体外研究EGFR-IN-146(Compound53)(10μM)effectivelypromotesglucoseabsorptionandplaysaroleinlowering

bloodsugarintheC2C12cellmodel[1].

REFERENCES

[1].NamKyuLee,etal.Quinazolinederivativesforthetreatmentandpreventionofdiabetesandobesity.WO2006071095A1.JP.2005-12-

30.

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