Avadomide-Standard-CC-122-Standard-生命科学试剂-MCE.pdfVIP

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Avadomide(Standard)

Cat.No.:HY-100507R

CASNo.:1015474-32-4

Synonyms:CC122(Standard)

分⼦式:C₁₄H₁₄N₄O₃

分⼦量:286.29

作⽤靶点:E1/E2/E3Enzyme;Apoptosis;MolecularGlues;NF-κB

作⽤通路:MetabolicEnzyme/Protease;Apoptosis;PROTAC;NF-κB

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Avadomide(Standard)是Avadomide的分析标准品。本产品⽤于研究及分析应⽤。Avadomide是⼝服有效

的cereblon调节剂。Avadomide可以调节cereblonE3连接酶活性，抑制NF-κB通路，在G1期阻滞细胞周

期，从⽽诱导癌细胞PDAC的细胞凋亡(apoptosis)。Avadomide具有抗肿瘤和免疫调节活性。

REFERENCES

[1].Hagner,P.R.etal.CC-122,apleiotropicpathwaymodifier,mimicsanIFNresponseandhasantitumoractivityinDLBCL.Blood.Aug

6;126(6):779-89.

[2].RascoDW,etal.AFirst-in-HumanStudyofNovelCereblonModulatorAvadomide(CC-122)inAdvancedMalignancies.ClinCancer

Res.2019Jan1;25(1):90-98.

[3].NishiH,etal.,Anti-tumoreffectofavadomideingemcitabine-resistantpancreaticductaladenocarcinoma.CancerChemother

Pharmacol.2023Oct;92(4):303-314.

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