P53-TLR2-modulator-1-生命科学试剂-MCE.pdf

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P53/TLR2modulator-1

Cat.No.:HY-173309

分⼦式:C₁₆H₁₁N₃O₂S

分⼦量:309.34

作⽤靶点:MDM-2/p53;Toll-likeReceptor(TLR);Apoptosis;MyD88;Bcl-

2Family;InterleukinRelated

作⽤通路:Apoptosis;Immunology/Inflammation

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性P53/TLR2modulator-1(CompoundZ9)是⼀种同时靶向P53通路和TLR2的调节剂，具有抗辐射活性。

P53/TLR2modulator-1通过抑制辐射诱导的P53和Bax表达，减少细胞凋亡(Apoptosis)；同时激活TLR2通

路，上调下游蛋⽩MyD88和P65的表达，促进细胞因⼦如IL-6的分泌，发挥抗辐射作⽤。P53/TLR2

modulator-1对AHH-1细胞和HUVECs细胞均展现出显著的抗辐射活性，并可提⾼受致死剂量辐射的

C57BL/6J⼩⿏的存活率，减轻辐射对其造⾎系统、⼩肠绒⽑结构和脾脏的损伤。P53/TLR2modulator-1可⽤

于辐射损伤相关疾病的研究[1]。

IC50TargetIL-6TLR2

REFERENCES

[1].HeZ,etal.DiscoveryofanovelquinoxalinederivativemodulatorviaadualP53/TLR2targetingstrategyforthealleviationofradiation

damage.EurJMedChem.2025Jun5;290:117505.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformed