HDAC-IN-27-dihydrochloride-生命科学试剂-MCE.pdf

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HDAC-IN-27dihydrochloride

Cat.No.:HY-142690A

CASNo.:3069831-25-7

分⼦式:C₂₀H₂₄Cl₂N₄O₂

分⼦量:423.34

作⽤靶点:Apoptosis;HDAC

作⽤通路:Apoptosis;CellCycle/DNADamage;Epigenetics

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性HDAC-IN-27dihydrochloride(Compound11h)是⼀种有效的、具有⼝服活性的HDACI类选择性抑制剂，对

HDAC1-3的IC50值范围为0.43⾄3.01nM。HDAC-IN-27dihydrochloride还具有体内和体外抗癌活性。

HDAC-IN-27对急性髓系⽩⾎病(AML)细胞系表现出显著的抗增殖活性，并通过诱导细胞凋亡(apoptosis)和

组蛋⽩⼄酰化(AcHH3和AcHH4)发挥作⽤。HDAC-IN-27dihydrochloride可以⽤于急性髓系⽩⾎病(AML)的

研究[1]。

IC50TargetHDAC1HDAC2HDAC3

3.01nM(IC50)18.54nM(IC50)0.435nM(IC50)

体外研究Inwt-p53MV4-11cells,HDAC-IN-27dihydrochloride(11h)leadstopro-caspase-3cleavage,apparent

apoptoticcelldeath,andaccumulationofsub-G1cellpopulationwhileinducingG2/MarrestinHL60cells