Kylo-0603-生命科学试剂-MCE.pdf

Hotline:400-820-3792

Inhibitors•ScreeningLibraries•Proteins

www.MedChemE

Kylo-0603

Cat.No.:HY-172661

CASNo.:2661053-09-2

分⼦式:C₈₁H₁₃₄N₈O₂₈

分⼦量:1667.97

作⽤靶点:ThyroidHormoneReceptor;InterleukinRelated;LDLR

作⽤通路:VitaminDRelated/NuclearReceptor;

Immunology/Inflammation;MetabolicEnzyme/Protease

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性KYLO-0603是⼀种⼝服有效的选择性THR-β激动剂(EC50:31.07nM)。KYLO-0603具有显著降低⾎清胆固醇

和低密度脂蛋⽩胆固醇的活性。KYLO-0603通过激活THR-β受体，上调THR调控基因的表达(包括碘甲状腺

原氨酸脱碘酶1(Dio1)、苹果酸酶1(Me1)和甲状腺激素反应(Thrsp)基因)和抑制炎症及纤维化基因(低密度脂

蛋⽩受体(LDL-R)基因)表达。KYLO-0603能够⽤于治疗代谢功能障碍相关脂肪性肝炎(MASH)和肝纤维化研

究[1]。

REFERENCES

[1].Xueqinlu,etal.KYLO-0603,anovelliver-targeting,thyroidhormonereceptor-βagonistforthetreatmentofMASH.bioRxiv

2025.02.09.637336

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

Forresearchuseonly.

Tel:400-820-3792;021