Flindersine-生命科学试剂-MCE.pdfVIP

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Flindersine

Cat.No.:HY-W984782

CASNo.:523-64-8

分⼦式:C₁₄H₁₃NO₂

分⼦量:227.26

作⽤靶点:GLUT;AMPK;PPAR;ReactiveOxygenSpecies(ROS)

作⽤通路:MembraneTransporter/IonChannel;Epigenetics;

PI3K/Akt/mTOR;CellCycle/DNADamage;Metabolic

Enzyme/Protease;VitaminDRelated/NuclearReceptor;

Immunology/Inflammation;NF-κB

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Flindersine是⼀种抗糖尿病和抗氧化剂。Flindersine可导致⼤⿏⾎糖⽔平下降。Flindersine还能降低体内体

重增长、⾎浆胰岛素浓度、尿素、肌酐、总胆固醇、⽢油三酯和游离脂肪酸⽔平。Flindersine可增强脂肪组织

和⾻骼肌中GLUT4、AMPK和PPARγ的磷酸化[1]。

REFERENCES

[1].Irudayaraj,S.S.,etal.,(2022).Antidiabeticwithantilipidemicandantioxidanteffectsofflindersinebyenhancedglucoseuptakethrough

GLUT4translocationandPPARγagonismintype2diabeticrats.Journalofethnopharmacology,285,114883.

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Caution:Producthasnotbeenfullyvalidatedformedicalapplications.