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Pyrraline

Cat.No.:HY-W478741

CASNo.:74509-14-1

分⼦式:C₁₂H₁₈N₂O₄

分⼦量:254.28

作⽤靶点:EndogenousMetabolite;Keap1-Nrf2;NF-κB

作⽤通路:MetabolicEnzyme/Protease;NF-κB

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Pyrraline是⼀种能激活Nrf2通路激活剂，具有抗氧化和抗炎作⽤。Pyrraline通过激活抗氧化反应元件(ARE)

来上调抗氧化酶，如NAD(P)H氧化酶(NQO1)和⾎红素加氧酶-1(HO-1)，同时抑制由NFκB介导的炎症反应

。Pyrraline有望⽤于代谢紊乱(如糖尿病肾病)和癌症的研究。

REFERENCES

[1].HuC,etal.Untargetedmetaboliteprofilingofseruminratsexposedtopyrraline.FoodSciBiotechnol.2023Jan26;32(11):1541-1549.

[2].RaupbachJ,etal.TheEffectofFreeandProtein-BoundMaillardReactionProductsN-ε-Carboxymethyllysine,N-ε-Fructosyllysine,and

PyrralineonNrf2andNFκBinHCT116Cells.MolNutrFoodRes.2023Sep;67(18):e2300137.

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