3-2-cGAMP-disodium-c-A-2-5-pG-3-5-p-disodium-生命科学试剂-MCE.pdfVIP

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32-cGAMPdisodium

Cat.No.:HY-137708A

Synonyms:c[A(2,5)pG(3,5)p]disodium

分⼦式:C₂₀H₂₂N₁₀Na₂O₁₃P₂

分⼦量:718.37

作⽤靶点:STING;NF-κB

作⽤通路:Immunology/Inflammation;NF-κB

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性32-cGAMP(c[A(2,5)pG(3,5)p])disodium是32-cGAMP(HY-137708)的⼆钠盐。32-cGAMP

(c[A(2,5)pG(3,5)p])是⼀种环状鸟苷酸-腺苷酸(cGAMP)异构体。32-cGAMP对果蝇STING(dSTING)表现出

⾼选择性，激活dSTING-NF-κB信号通路，诱导Sting调控基因的表达，并在体内赋予强效的抗病毒状态。

32-cGAMP能够抵抗病毒poxin的切割。32-cGAMP可⽤于病毒感染研究[1]。

REFERENCES

[1].SlavikKM,etal.cGAS-likereceptorssenseRNAandcontrol32-cGAMPsignallinginDrosophila.Nature.2021Sep;597(7874):109-

113.

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