【2026年整理】2Pharmacokinetics精品课件.pptVIP

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【2026年整理】2Pharmacokinetics精品课件.ppt

Chapter2

Pharmacokinetics

;Pharmacokinetics;Part1

Transmembranetransportofdrugs;;Thestructureofcellmembrane?

Howtotransportit?;Transmembranetransport;Passivetransport(downhillmovement);Affectingfactors:

thesizeofmolecule

lipidsolubility

polarity

degreeofionization

thePHoftheenvironment

suchas:fluidofbody

fluidincell

blood,urine;Generallyspeaking

ThedrugswhichareUnionized,lowpolarityandhigherlipidsolubilityareeasytopermeatemembrane.

Thedrugswhichareioniz

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