干湿法制粒技术在片剂生产中的对比应用.pdf

齐鲁药事# Qilu Pharmaceut ical Af fairs 2009 Vol1 28 , N o14 # 24 9 # 4 值。 遗尿症属于儿童疑难病症, 长期尿床容易引起患儿羞 愧、胆怯、恐惧、多动、焦虑的心 ,造成性格缺陷, 记忆力差, [ 1]季宇彬1 抗癌中药药 与应用1 黑龙江:科学技术出版社, 1999: 注意力不集中, 智商下降, 严重影响儿童的身心健康。中药 5661 [2]唐汗钧, 汝丽娟1 中国民间外治独特疗法1 上海:上海科学技术 粉饼敷脐联合穴位艾灸, 为治疗儿童遗尿症创造了一种新方 出版社, 2004:321 法, 该方法操作简便, 疗效确切,有着较高的临床推广应用价 # # ,,, ( , 266101) : ( QK ) ( FM ) , 。 (SF ) (GF ) QK FM , 、、、、 。 SF ,GF , (FM ) 。 GF , SF ,, 。 : : R9441 4 : A : 1672- 773 8( 2009) 04 - 0249- 03 The tablet production contrast application of dry andwet granulation HU Jie, YU Hua2zhi, CH N Ying, WU Kang ( Qingdao Huanghai Pharmaceutical Limited Company, Qingdao 266101) ABSTRACT:OBJECTI E Troxerutin tablets ( QK) and phosphoesterases complex t ablets ( FM) were produced by wet granulation (SF) and dry granulation ( GF)1 Compare granules and tablet s to show which technology is good1 METHODS QK and FM produced three batches by SF and GF respectively1 To analytical and compare the data of particle size distribution, an2 gle of repose, compressibility, the contents/ effect prices, and the accelerated t esting for six months1 RESULTS The Liquidity and pressure of particle which produced by GF is slightly less than SF, but the stability of some thermal inst ability drugs ( such as FM) is better than SF1 CONCLUSION The GF technology has a greater advant age in many aspects1 The dosage of materials in the prescription adjusted1 It can be more widely used1 KEY WORDS:Troxerutin;phosphoesterase; wet granulation;dry granulation 干法制粒工艺(GF