论文The_frameless_copper_IUD_(GyneFix)_and_the_TCu380A_IUD.pdfVIP

Contraception 80 (2009) 133 – 141 Original research article The frameless copper IUD (GyneFix) and the TCu380A IUD: results of an 8-year multicenter randomized comparative trial☆,☆☆,★ a,b,⁎ c a a d Olav Meirik , Patrick J. Rowe , Alexandre Peregoudov , Gilda Piaggio , Max Petzold for the IUD Research Group at the UNDP/UNFPA/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction a UNDP/UNFPA/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction, 1211 Geneva 27, Switzerland bInstituto Chileno de Medicina Reproductiva (ICMER), 8320162 Santiago, Chile c Vesancy, 01170 Gex, France dNordic School of Public Health, 402 42 Gothenburg, Sweden Received 18 November 2008; revised 5 February 2009; accepted 5 February 2009 Abstract Background: Clinical performance of the frameless copper IUD (GyneFix), designed to reduce side effects related to the frame of conventional IUDs, and TCu380A was compared. Study Design: Randomized Multicenter randomized comparative trial. Parous women requesting and eligible to use IUD were admitted in 21 centers in eight countries in 1989–1993 and followed-up for up to 8 years. Results: Two thousand twenty-seven women were randomized to the frameless IUD and 2036 to TCu380A; 43 insertions of the frameless IUD failed and none for TCu380A. First-year expulsion rate of the frameless IUD was 5.3 (95% CI: 4.4–6.4) per 100