美国数学建模竞赛特等奖论文——2003 B M Optimization of Stereotactic Radiosurgery Treatment Planning【数学建模】.pdfVIP

Team # 163 Page 1 of 11 Optimization of Stereotactic Radiosurgery Treatment Planning Introduction Gamma knife, which uses stereotactic radiosurgery, is extensively used to treat a wide range of cancers. This therapy satisfies our needs by destroying locus as a result of enough radiation, while avoiding unnecessary damage to the surrounding tissue and organs. In the field of medicine, we can get optimal results if the dosage inside average tumor reaches above 50% . Our model, during the whole treating course, is considered as a bulk composed of a group of isodose curves, which have the same center, inside the tumor. Guaranteeing the safety of surrounding tissues, we only take into account the volume relationship between the tumor and what 50% isodose curve encompasses. Through discrete digital calculating, we can decide optimal shots, locations, beam channels’ diameters and all these parameters make 50% isodose curve coincide with tumor’s contour. We also analyzed more difficult situations (see Figure 0). The small ball stands for the critical tissue, which must be outside the curve surface enclosed by a certain dosage curve. We designed a computer program to deal with varieties of tumors’ shapes, which can be produced through continuous curve surface’s equation or discrete data. Applying geometrical and physical laws, this treating course can be simulated as a sphere-packing problem. Tumor’s external is imagined to be firm and mustn’t be protruded by 50% isodose curve. When the requests of volume, dosage and gradient are met, packing will stop. Analysis of the Problem Acco