药理学课件__2药物代谢动力学.pptVIP

第二章 药物代谢动力学Pharmacokinetics Figure 1. Mean gepirone plasma concentrationsfollowing administration of gepirone-IR formulations(10mgq12 h,n=12) or gepirone-ER formulations (ER-1:20 mg q24 h, n=12; ER-2: 20 mg q24 h, n=12; ER-3:25 mg q24 h, n=12). Figure 2. Mean 1-PP plasma concentrations followingadministration of gepirone-IR formulations(10 mg q12 h, n=12) or gepirone-ER formulations (ER-1: 20 mg q24 h, n=12; ER-2: 20 mg q24 h, n=12; ER-3:25 mg q24 h, n=12). * * Transformation Free Systemic Circulation Bound drug Free drug Metabolites Locus of Action “receptors” Bound Free Tissue Res