药理学课件__17抗中枢退行性疾病药.pptVIP

抗中枢退行性疾病药 抗帕金森病药 PARKINSONISM (Paralysis Agitants) Parkinsonism is characterized by a combination of rigidity, bradykinesia, tremor, and postural instability that can occur for a wide variety of reasons but is usually idiopathic. The pathophysiologic basis of the idiopathic disorder may relate to exposure to some unrecognized neurotoxin or to the occurrence of oxidation reactions with the generation of free radicals. Studies in twins suggest that genetic factors may also be important, especially when the disease occurs in patients under age 50. Parkinsons disease is generally progressive,