药理学课件__24利尿药.pptVIP

Major points Physiological and pharmacological basis of diuretics Pharmacology of diuretics Diuretics and dehydrant agents Diuretics: increase urine flow, increase Na+ excretion accompanying Cl- Dehydrant agents(Osmotic diuretics): freely filtered at the glomerulus, limited reabsorption by the renal tubule, relative inert pharmacologically. Effects of aldosterone Activation of Na+ channels Redistribution of Na+ channel from cytosol to membrane Synthesis of Na+ channels Redistribution of Na+/K+ ATPase channel from cytosol to membrane Synthesis of Na+ /K+ ATPase channels Increase of mitochond