药理学课件_Chapter_7__anticholinesterase_agents_amp;_cholinesterase_reactivators.pptVIP

Neostigmine（新斯的明） 1. Pharmacological effects ①cholinesterase inhibitor ②very strong effect on skeletal muscle --direct activating N2 receptors --release ACh at the motor nerve endings（运动神经） ③strong stimulating effect on gastrointestinal tract（胃肠道平滑肌） and gallbladder smooth muscle（胆囊平滑肌） Pyridostigmine（吡斯的明） 1.Similar and weaker than neostigmine 2.Duration is longer? 3.Clinical Uses ①myasthenia gravis? ②postoperative intestinal distention and urinary retention ③less side effects Physostigmine(毒扁豆碱，又称Eserine） Clinical Uses ①glaucoma（青光眼） ②awakening of trad