药理学课件_Chapter_8,9__Anticholinergic_drugs.pptVIP

Atropine（阿托品）, An alkaloid that affects the nervous system 1.Mechanism of Action ①Competitive antagonism（对抗） of ACh to muscarinic receptors ②Not distinguish among M1, M2, M3 ③Most sensitive tissues: salivary, bronchial and sweat glands ④Less sensitive: gastric parietal cells（壁细胞）(gastric acid secretion) ⑤Intermediate: smooth muscle effectors and the heart 2. Pharmacological Effects ①Inhibition the secretion of gland a.salivary gland(dry mouth) b.sweat gland(dry skin) c.bronchial secretary gland d.large dosage---inhibits the secretary function of the stomach ②