药理学英文版课件_第14章_局部麻_醉药.pptVIP

* Chapter 14 局部麻醉药 Local anesthetics Teaching goals (教学目标) 1、简述局麻原理及局麻方式 2、比较常用局麻药特点 Definition （定义） Local anesthetics (LAs) are drugs that block both the generation(产生) and the conduction （传导）of the nerve impulse（冲动） when applied locally to nerve tissue in appropriate （适当的）concentrations. Local anesthetics produce the reversible（可逆的）loss of sensation without the loss of consciousness. The first local anesthetic to be discovered was cocaine (可卡因). Owing to its addiction(成瘾), its clinical use was limited. A chemical search for synthetic(合成的) substitutes(代用品) for cocaine star