注射用盐酸氨溴索溶解方法及与常用药物配伍稳定性考察.pdfVIP

药物与临床 Drugs and Clinic 注射用盐酸氨溴索溶解方法及与常用药物配伍稳 定性考察 * 司延斌，赵志刚 首都医科大学附属北京天坛医院药剂科，北京 100050 摘要：目的：考察在室温条件下注射用盐酸氨溴索溶解方法及与多种临床常用药物配伍稳定性。方法：模拟临床配制方法， 将盐酸氨溴索与常用溶媒及临床常用药物配伍后，观察溶液pH值和澄清度变化。结果：盐酸氨溴索在常用溶媒中8小时内PH值 与溶液澄清度保持稳定，但溶媒量减少后出现浑浊现象。药物与一些注射剂如头孢呋辛、亚胺培南西司他丁、美罗培南、氨 茶碱、二羟丙茶碱、地塞米松、氢化可的松、甲泼尼龙、奥美拉唑、维生素C及呋噻米配伍后产生白色浑浊。结论：注射用盐 酸氨溴索最好选用葡萄糖作为稀释溶媒，溶解药物时，一次抽液量不宜少于5ml。本品不宜与头孢呋辛、亚胺培南西司他丁、 美罗培南、氨茶碱、二羟丙茶碱、地塞米松、氢化可的松、甲泼尼龙、奥美拉唑、维生素C及呋噻米等注射剂药物配伍。 关键词: 注射用盐酸氨溴索；溶解方法；配伍稳定性 [中图分类号]R974　　[文献标识码]A　　[文章编号]1672－2809（2010）06-046-03 Dissolution Method and Compatibility of Ambroxol Hydrochloride for Inj ection with Drugs SI Yan-bin ，ZHAO Zhi-gang* Department of Pharmacy, Beij ing Tiantan Hospital Affiliated to Capital Medical University, Beij ing 100050 Abstract: Obj ective: To study the dissolution method and compatibility with ambroxol hydrochloride inj ection drugs under normal atmosphere temperature. Methods: The changes of clarity and pH values of solution were observed after mixing with common solvents and drugs. by simalation of clinical perparation me thod. Results: clarity and pH values remained stable in 8 hours after mixing with common solvents. But there is the phenomenon of turbidity in less volume solvents. White turbidity appeared after mixing ambroxol hydrochloride with cefur oxim e, imip en em an d cilast atin, m er op en em, amin ophyllin e, dipr ophyllin e, dexam eth ason e, hydrocortisone, methylprednisolone, omeprazole, vitamin C and furosemide inj ection . Conclusions: Glucose was the most appropriate dilution of solvent for ambroxol hydrochloride, and pumping liquid volume should not be less than 5ml once when dissolving drugs. Ambroxol hydrochloride can not be compatible with cefuroxime ， imipenem and cilastatin ，meropenem ，aminophylline ，diprophylline ，dexamethasone ，hydrocortisone ， methylprednisolone ，omeprazole ，vitamin C and furosemide inj ection. Key Words ：Ambroxol