Drug Delivery System药物投递系统.ppt

Drug Delivery System藥物投遞系統 生科系04級 黃玫璇 891672 生科系04級 許哲源 891659 生科系04級 蕭宏展 891631 生科系04級 楊淳竣 891625 藥物釋控系統 黃玫璇 891672 Controlled Release vs. Single Dose 【 Diffusion controlled】 Diffusion through membrane or bulk polymer 【 Chemically controlled】 ˙ polymer erosion： surface erosion, bulk erosion ( combination of erosion and diffusion ) ˙ pendent chain 【 Solvent-activated controlled】 ˙ osmotic transport of water through semi permeable membrane ˙ water penetration into glassy polymer Targeting moiety for cell 891659 許哲源 Introduction For the past several decades, researchers and clinicians have been using drugs and radiation to kill tumor cells. The chemotherapy and radiotherapy are only semiselective for malignant cells. In contrast, targeting drug therapy has the potential for greater specificity. With the advent of monoclonal antibody (MoAb) technology, researcher have been able to target different agents to target cells more effectively. EPR effect The Enhanced Permeability and Retention effect in tumor tissue Tumor cells show a higher degree of uptake of macromolecules by endocytosis than normal cell. Introduction Immunotoxins (Its) contain a targeting moiety for delivery and a toxic moiety for cytotoxicity. The toxins ( plant or bacterial toxin) are catalytic, fewer than 10 molecules in the cytosol of a target cell enough to be lethal. Schematic presentation of ligand-containing, shielded DNA complexes for tumor-targeted gene transfer Targeting Moiety The targeting agents currently used to construct ITs are MoAbs, growth factors/cytokines, and soluble receptors. MoAbs are the most frequently used. Targeting Moiety Targeting Moiety Bispecific antibodies are novel targeting agents constructed by linking either chemically or genetically two different Fab fragment, one arm of which is directed against a target cell and the other against effector T cells or NK cells (e.g. anti-CD22/anti-CD3-RTA). Toxin Moiety The most commonly used tox