可降解镁合金作为骨植入材料的体内研究进展.pdfVIP

2012 11 26 11 中国修复重建外科杂志 年 月第 卷第 期 1381 · · • 综 述• 可降解镁合金作为骨植入材料的体内研究进展 齐峥嵘 张强 殷毅 王岩 【摘  要】    目的 综述可降解镁合金作为骨植入材料的体内研究进展。 方法 查阅近年有关可降解镁合金在骨 科领域体内研究的相关文献，并进行总结。 结果 镁合金能通过化学腐蚀在体内缓慢降解，极具潜力成为骨植入材料。 近年在镁合金生物相容性、降解速度、植入材料- 骨组织界面强度等方面的研究取得了较大进展，但镁合金的体内降解机 制、对生物体的作用尤其是远期影响还缺乏系统研究，镁合金的体内降解速度亦未得到有效控制。 结论 可降解镁合 金作为骨植入材料具有巨大潜力，但在应用于临床前仍需进行深入、系统的体内研究。 【关键词】 可降解材料 镁合金 骨植入材料 PROGRESS OF IN VIVO STUDY ON DEGRADABLE MAGNESIUM ALLOYS APPLICATION AS BONE-IMPLANT MATERIALS/QI Zhengrong, ZHANG Qiang, YIN Yi, WANG Yan. Department of Orthopaedics, General Hospital of Chinese PLA, Beijing, 100853, P.R.China. Corresponding author: WANG Yan, E-mail: yanwang301@ 【Abstract 】 Objective To review the progress of in vivo study on degradable magnesium alloys application as bone- implant materials. Methods Recent literature was extensively reviewed and summarized, concerning the in vivo study on degradable magnesium alloys as orthopaedic implants. Results Magnesium alloys possess a natural ability to degrade via corrosion in vivo, which is promising candidate material for orthopaedic medical device applications. A great progress has been made to improve in vivo performance and integration with bone tissue. However, the degradation mechanism of magnesium- based materials in the physiological environment and long-term effect on body are not available. The modulation of the corrosion rate of magnesium alloys must also be accompl