SF_COL_PLLA和SF_COL_PLCL静电纺复合纤维的制备及其力学性能的研究.docVIP

  SF/COL/PLLA 和 SF/COL/PLCL 静电纺复合纤 维的制备及其力学性能的研究# 1,2 1 1 1 1 1**  5 10  （1. 兰州大学口腔医学院,甘肃兰州 730000； 2. 甘肃省卫生学校,甘肃兰州 730000） 摘要：目前，将天然高分子蛋白和聚合物共混利用静电纺丝法制作各种组织工程支架材料倍受关注。基于 这种研究背景，在本文中利用静电纺丝技术，制备了丝素（SF）/胶原(COL)/ 聚左旋乳酸（PLLA）和 SF/COL/ 聚左旋乳酸- 己内酯（PLCL）两种共混复合纤维膜，通过扫描电镜(SEM)对纤维形态结构分析，发现复合纤 维形貌良好，直径较为均一。同时改变纺丝液中高分子蛋白的比例，复合纤维的直径也随之减小。此外， 对复合纤维进行了力学性能测试，发现随着聚合物含量的增加，复合纤维膜的力学性能得以改善， SF/COL/PLCL 组复合纤维的拉伸性能明显优于 SF/COL/PLLA 组。 关键词：静电纺丝；丝素；胶原；聚左旋乳酸；聚左旋乳酸- 己内酯；力学性能 中图分类号：R318.08 15 Preparation of SF/COL/PLLA and SF/COL/PLCL electrospun composite fibers and its mechanical properties study WANG Lin1,2, WANG Hong1, HUANG Songtao1, ZHANG Zhongrui1, YIN Lihua1, YU Zhanhai1 20 25 30 (1. Stomatological College of Lanzhou University,Gansu Lanzhou 730000; 2. Gansu Province Health School,Gansu Lanzhou 730000) Abstract: At present, the method which blends natural polymeric protein with polymer to fabricate a variety of materials for tissue engineering scaffolds through using electrospinning technique has attracted much attention. Based on this research background, in the paper, two new composite fibers from Silk fibroin (SF)/Collagen (COL)/poly-L-lactide (PLLA) and Silk Fibroin (SF)/Collagen (COL)/ poly(L-actic-co-ε-caprolactone) (PLCL) are made by electrospinning. The surface morphologies of composite fibers can be observed by Scanning Electron Microscopy (SEM). The measured results show two new composite fibers have good morphologies and uniform diameters. At the same time, the observed results suggest that their diameter become more and more small while the ratio of the polymeric proteinis varied. Additionally, the mechanical measurements reveal that the mechanical properties improved with the increasing content of polymer in composite fiber membranes. As a result, the tensile properties of the SF/COL/PLCL composite fiber membranes were better than those of SF/COL/PLLA composite fiber membranes. Key words: Electrospinning; SF; COL; PLLA; PLCL; Mechanica