年产4kt羟乙基淀粉1300.4设计说明书.docVIP

（ 二 〇 一 三 年 六 月 摘 要 羟乙基淀粉是支链淀粉经过降解后再与羟乙基化试剂反应得到的产物。它是一种优良的血浆代用品，被用作血浆体积增量剂及冻结或融化期间作为保护血细胞的介质，因此临床上在失血性、创伤性、感染性和中毒性休克等疾病治疗方面被广泛使用。 由于羟乙基化试剂与淀粉中羟基发生反应的差异性，使得羟乙基淀粉衍生出不同分子量、摩尔取代度及C2/C6值的产品。本设计为年产4000吨羟乙基淀粉130/0.4的设计计算，即平均分子量为130000，平均摩尔取代度为0.4的羟乙基淀粉的合成计算。合成羟乙基淀粉130/0.4采用可靠地淀粉水解与羟乙基化工艺。采用医药用玉米支链淀粉与环氧乙烷合成，由于玉米淀粉含有约95％130/0.4 Abstract Hydroxyethyl starch, a product that the degraded amylopectin reacts with hydroxyethyle reagent,is a excellent plasma substitutes, For instance,it is used as a treatment as a plasma volume extender and as interface that protects cells from being freezed or thawed. As a consequence, it is widely applied as a treatment in some diseases such as blood loss, trauma, infectious and toxic shock etc. . The difference of reaction between hydroxyethyl reagent and hydrol of starch leads to product with distinct molecular weight,molar substitution degree and C2/C6. The calculations of the thesis are based on the annual output 4000 tons hydroxyethyl starch 130/0.4,which means the average molecular weight of hydroxyethyl starch is 130000,and the molar substitution of it is 0.4. Meanwhile ,in the paper,synthesis of hydroxyethyl starch 130/0.4 adopts starch hydrolysis and hydroxyethyl reaction process,and synthetized by the reaction of corn starch with epoxy ethane. Moreover ,corn starch contains about 95％ amylopectin and those amylopectin have vivo-glycogen-like collateral sugar chain,which reduces the risk of allergic reaction, In addition,modified starch can throughly dissolve into water, and amylase hydrolysis resistence to it decline. This ensures hydroxyethyl starch solution as the generation of plasma which can maintain longer life activities. Keywords: plasma substitutes;synthesis;hydroxyethyl starch 130/0.4 目 录 引 言 1 第一章 羟乙基淀粉概述 2 1.1 淀粉及改性淀粉 2 1.1.1 淀粉 2 1.1.2 淀粉改性 3 1.2 羟乙基淀粉概述 3 1.2.1 羟乙基淀粉的工业合成方法及其特性表征 3 1.2.2 羟乙基淀粉的用途 4 1.2.3 本设计生产羟乙基淀粉130/0.4的具体工艺 5 第二章 物料与热量衡算 5 2.1 物料衡算 6 2.1.1 生产任务 6