食管癌患者手术前后血清同型半胱氨酸水平检测的临床意义.pdfVIP

壁堕堡窒皇堕鏖垫!!生!!旦筮丝鲞筮!兰塑垦塑!竺垦!!!!些!丛堡!墅璺!里!!!堂箜垫!兰：!丛：丝：型!：!兰 ·825· ·论著· 食管癌患者手术前后血清同型半胱氨酸水平 检测的临床意义 陈芸韩存芝张双平王春利 【摘要】 目的探讨食管癌患者手术前后血清同型半胱氨酸(Hcy)水平变化及其临床意义。方 法采用循环酶法检测168例食管癌患者和50名对照者外周血Hey水平。结果食管癌组外周血Hey 水平明显高于对照组【(19．6士6．1)Ixmol／L比(13．0±2．3)斗mol／L，P=0．001】；食管癌患者术后第5 天、术后1个月、3个月血清Hey水平显著低于术前【(17．0±8．5)、(15．8±6．4)、(12．8±5．6)IJJmol／L比 (20．6±9．1)Ixmol／L，均Po．05)1；术后3个月血清Hcy水平接近于对照组；T4患者血清Hcy水平高于 瘤长度5 am、3—5 am组血清Hey水平明显高于3 cm组『(23．6±9．6)Ixmol／L比(18．1±6．3)、 (19．6±6．6)斗mol／L，P=0．036、P：0．021]；淋巴结转移与否食管癌患者的血清Hcy水平差异无统计学意 义【(20．2±9．3)斗mol／L比(20．3±7．6)I^mol／L，P=0．897]，脉管阳性组血清Hey水平低于阴性组 关。 【关键词】食管肿瘤；同型半胱氨酸 CHmcal ofserum leveldetectedbeforeandafter in significancehomocysteine surgeryesophageal CHEN NG cancer Yun8，HANCun-zhi，ZHA NG patients Shuang-ping,WAChun—ti．+Departmentof Cancer Room,ShanxiHospital,Taiyuan030013，China opcrating author：HAN CorrespondingCun-zhi，Email：byshcz@vip．163．eom Toevaluatethe andclinical oftheserumlevelof 【Abstract】0bjectivechanges significance cancer beforeandafter MethodsTheserum homocysteine(Hcy)inesophagealpatients surgery． Hcy with and50 concentrationsof168 cancer individualsweremeasured patientsesophageal healthy byenzymatic Total levelswere raisedin when withthelevels cycling．ResultsHey significantlypatientsgroup compared incontrol levelswere lowerin group【(19．6+6．1)Ixmol／LVS(13．0±2．3)I^mol／L，P=0．001]．Hcysignificantly with VS postoperativepatientsgroupscomparedpreoperativ