β-七叶皂甙钠与丹参联用治疗胶质瘤术后脑水肿的疗效观察.pdfVIP

《现代仪器与医疗》 2014年  第20卷   第1期 临床研究 β-七叶皂甙钠与丹参联用治疗胶质瘤 术后脑水肿的疗效观察 佟建洲　潘勤　佟中豪　李连进　贺建辉　范经世　贾振岭　甘宁 （保定市第一中心医院神经外科，保定　071000 ） [ 摘　要 ]　目的 ：观察β- 七叶皂甙钠及丹参联合应用治疗胶质瘤术后病人脑水肿的疗效。方 法 ：胶质瘤术后脑水肿病人85 例，随机分为4 组，其中常规甘露醇组、β- 七叶皂甙钠组以及 丹参组作为对照组，联合组作为试验组。每组病例均给予甘露醇、营养神经等常规治疗，β- 七叶皂甙钠组同时加用β- 七叶皂甙钠注射液治疗，丹参组同时加用丹参注射液治疗，联合组 加用丹参及β- 七叶皂甙钠注射液进行治疗，以患者意识状态、颅内压及CT 结果作为评判标准。 结果 ：联合组脱水、降颅压显效率及意识好转比例显著高于对照组（p ＜0.05 ），差异有统计学 意义；治疗起效时间短于对照组。结论 ：β- 七叶皂甙钠及丹参联合应用治疗胶质瘤术后脑水 肿起效时间更快，疗效更好，并可促进神经功能的恢复。 [ 关键词 ]　β- 七叶皂甙钠；丹参；脑水肿；胶质瘤；术后 中图分类号： R742　文献标识码：A　文章编号：2055-5200(2014)01-047-04 Doi:10.11876/mimt201401012 Clinical observation of therapeutic effects of β-aescinate and Salvia combination  Therapy in treating cerebral edema of patients after gliomas operation TONG Jian- 　 zhou, PAN Qin, TONG Zhong-hao, LI Lian-jin, HE Jian-hui, FAN Jing-shi, JIA Zhen- ling, GAN Ning. Department of neurosurgery, Baoding No.1 central hospital, Baoding, （ 071000 ） [Abstract]　Objective ：To observe the therapeutic effects ofβ-aescinate and Salvia combination Therapy in treatingpostoperative cerebral edema of patients with gliomas Methods 85 cases of postoperative cerebral edema of gliomas were randomly divided into four groups, in which mannitol group, β-aescinate group and Salvia group as the control groups, the joint group as a test group. Each group of patients treated with the conventional mannitol and other rehabilitation t reatment, in addition, the β-aescinategroup added in the β-aescinate injection, the Salvia group were added Salvia injection, the joint group were given both Salvia and β-aescinate injection. Results The joint group’s effect ondehydration and reduce intracranial pressure was significantly higherthan the controls, and the treatment onset time was significantly shorter than the contr