降钙素基因相关肽家族在疼痛和阿片耐受中的作用.pdfVIP

生理学报Acta Physiologica Sinica , June 25, 2013, 65(3): 347–354 347 综 述 降钙素基因相关肽家族在疼痛和阿片耐受中的作用 * 刘芳薇，洪炎国 福建师范大学生命科学学院，福建省发育和神经生物学重点实验室，福州 350108 摘 要：降钙素基因相关肽(calcitonin gene-related peptide, CGRP)家族成员主要包括CGRPα 、CGRPβ 、肾上腺髓质素 (adrenomedullin, AM) (calcitonin, CT) (amylin, AMY) CGRP 、降钙素 和胰淀粉样蛋白 。 家族成员及其受体广泛分布于哺乳动物 CGRP AM CGRP 中枢和外周神经系统。研究表明， 、 等 家族成员在伤害性信息传递过程中具有重要作用。在脊髓水平， CGRP促进痛觉信息传递、脊髓阿片耐受、偏头痛、炎性痛和神经病理性痛；在脊髓以上水平，CGRP则抑制痛觉信息的传 AM 递。 是近年来才证实的与疼痛感受有密切关系的神经多肽，在脊髓水平促进痛觉信息的传递，在阿片耐受形成和维持中 AMY CT 亦有重要作用。 和 与疼痛的关系尚不十分明确。 关键词：降钙素基因相关肽；肾上腺髓质素；疼痛；阿片耐受 中图分类号：R426 Roles of calcitonin gene-related peptide family in pain and opioid tolerance LIU Fang-Wei, HONG Yan-Guo* Provincial Key Laboratory of Developmental Biology and Neuroscience, College of Life Sciences, Fujian Normal University, Fuzhou 350108, China Abstract: The calcitonin gene-related peptide (CGRP) family mainly includes CGRPα, CGRPβ, adrenomedullin, calcitonin and amy- lin. The members of CGRP family and their receptors are widely distributed in the central and peripheral nervous systems. Studies show that members of CGRP family such as CGRP and adrenomedullin play important roles in the transmission of nociceptive infor- mation. At spinal level, CGRP promotes the transmission of nociceptive information, spinal morphine tolerance, migraine, inflamma- tory pain and neuropathic pain. At superspinal level, CGRP suppresses the transmission of nociceptive information. Adrenomedullin is a pain-related neuropeptide which has recently been demonstrated. It facilitates the transmission of nociceptive information and is involved in the development and maintenance of opioid tolerance. The involvement of amylin and calcitonin in pain is not clear yet. Key words: calcitonin ge