术前负荷剂量国产氯吡格雷在急性ST 段抬高型心肌梗死介入治疗中的疗效观察.pdfVIP

《中国医学前沿杂志 （电子版）》2013 年第5 卷第10 期 ●深圳信立泰专栏 ● 65 术前负荷剂量国产氯吡格雷在急性ST 段 抬高型心肌梗死介入治疗中的疗效观察 贺铿，石刚，赵勇，叶君明 （萍乡市人民医院　心内科，萍乡　337055 ） 【摘要】目的　比较国产氯吡格雷与进口氯吡格雷在急性ST 段抬高型心肌梗死介入治疗中的疗效及安 全性。方法　120 例急性ST 段抬高型心肌梗死患者，随机分为两组，国产氯吡格雷组：58 例；进口氯 吡格雷组：62 例。均在经皮冠状动脉介入治疗 （PCI ）术前口服负荷剂量600 mg/ 次、术后75 mg/d 。分 别观察两组PCI 基本特征，9 个月的主要临床心血管事件及出血事件、药物不良反应的发生情况。结 P ＞0.05 ）。 果　国产氯吡格雷组在心血管事件与出血、药物不良反应与进口氯吡格雷组差异无显著性 （ 结论　国产氯吡格雷与进口氯吡格雷在急性ST 段抬高型心肌梗死PCI 治疗同样安全、有效，但国产氯 吡格雷经济效益较进口氯吡格雷高，更适合在我国广泛应用。 【关键词】心肌梗死；氯吡格雷；经皮冠状动脉介入治疗 The effect observation of preoperative loading dose of domestic clopidogrel in PCI of acute ST- segment elevation myocardial infarction interventional HE keng, SHI gang, ZHAO yong, YE Jun-ming (Department of Cardiovascular Medicine, Jiangxi Pingxiang Peoples Hospital, PingXiang 337055, China) Corresponding author: HE keng, E-mail: waterflue@ Abstract Objective To compare the therapeutic effects and safety of domestic clopidogrel and import 【 】 　 clopidogrel on PCI in acute ST-segment elevation myocardial infarction(STEMI) patients. Methods　120 patients with acute STEMI were randomly divided into domestic clopidogrel group(58 cases) and imported clopidogrel group(62 cases). Before PCI the two groups were respectively given loading dose of domestic or import clopidogrel 600mg; after PCI they were respectively given 75mg every day for nine months. Major clinical cardiovascular events, bleeding events and adverse reaction were observed in the two groups. Results　 There were no significant difference in cardiovascular events (P ＞0.05), adverse reaction (P ＞0.05), bleeding events P 0.05) between domestic clopidogrel group and import clopidogrel group. Conclusion Domestic ( ＞ 　 clopidogrel is as safe and effective as import clopidogrel in PCI of acute STEMI. Domestic