英语科普小知识 改变蚊子基因以控制疾病传播.docVIP

Virginia Tech researchers successfully used a gene disruption technique to change the eye color of a mosquito -- a critical step toward new genetic strategies aimed at disrupting the transmission of diseases such as?dengue fever（登革热）. Zach Adelman and Kevin Myles, both associate professors of?entomology（昆虫学）?in the College of Agriculture and Life Sciences and affiliated researchers with the Fralin Life Science Institute, study the transmission of vector-borne diseases and develop novel methods of control, based on genetics. ? In a groundbreaking study published this week in the journal PLOS One, the scientists used a pair of engineered proteins to cut DNA in a site-specific manner to disrupt a targeted gene in the mosquito genome. Science magazine heralded these transcription activator-like effector nuclease proteins, known as TALENS, as a major scientific breakthrough in 2012, nicknaming them genomic cruise missiles for their ability to allow researchers to target specific locations with great efficiency. ? While TALENS have been previously used to edit the genomes of animal and human cell cultures, applying them to the mosquito genome is a new approach, according to Adelman. ? Unlike model organisms with large collections of mutant strains to draw upon, the lack of reverse genetic tools in the mosquito has made it is very difficult to assign functions to genes in a definitive manner, Adelman said. With the development of this technology, our understanding of the genetic basis of many critical behaviors such as blood-feeding, host-seeking and pathogen transmission should be greatly accelerated. ? To test the capability of TALENs to specifically edit the mosquito genome, the scientists designed a pair of TALENS to target a gene whose protein product is essential to the production of eye?pigmentation（染色）?in Aedes aegypti, a mosquito species known for its transmission of the viruses that cause dengue fever. ? Using the TALEN pair to edit the gene in the mosquitos germ