SOCS-2和SOCS-3通过IGF-1和GH信号转导系统作用于成肌细胞的分化.pdfVIP

第25卷第4期 阜阳师范学院学报 (自然科学版) VoI．25。No．4 2008年 l2月 JournalofFuyangTeachersCollege(NaturalScience) Dee．2008 SOCS一2andSOCS-3areRelatedtoM yoblastDifferentiation viatheIGF一1andGH SignalingTransduction System LIU Wu—yi ，ZHAO Chun—jiangH ，WU Chang—xin (1．CollegeofAnimalScienceandTechnology，ChinaAgriculturalUniversity，Be ng，100093； 2．FuyangTeachersCollege，Fuyang，AnhuiProvince，236041) Abstract：Arecentlydescribedfamilyofproteins，thesuppressorofcytokinesignaling(SOCS)family，which actsinanegativefeedbacklooptoregulategrowthfactorsignalingorcytokineviatheJanuskinasesignaltransducer andactivatoroftranscription (JAK—STAT)pathway，hasbeen muchreported，andsomestudiessuggestthat SOCS一3playsakeyroleinmyoblastdifferentiationandsuppressingofinterleukin一6mediatedcellarinflammatory． W ith thebulkofreportsabouttheSOCSfamily，thispaperreviewsthestudiesontherelevanceofSOCS一2and SOCS一3totheIGF一1(insulin—likegrowthfactor1)andGH (growthhormone)signalingsystem．especiallyfocusing o12theroleofSOCs一3jnthemyoblastdifferentiation．TheresultsofthepreviousstudiessuggestthattheSOCS一2 andSOCS一3maybepotentialintercellularproteinfactorstoactonthegrowthfactorsignalingandSOCS．3probably hasanacceleratingeffectonanimalmuscledevelopment． Keywords：SOCS；SOCS一2；SOCS一3；IGF一1；IGF．2；GH ；JAK—STAT Pathway；myogenesis CLC number：Q78 Documentcode：A ArticleID ：1004—4329(2008)04—0001—08 A familyofSOCS (suppressorofcytokinesig— beinducedbycytokinesandtofunctioninpartofa naling)proteinshavingasimilardomainstructure negativefeedback loop to inhibiteytokinesignal hasrecentlybeenmuchdescribed．TheSOCSfami— transduction，suchasJAK—STAT