肿瘤生物治疗的新方法——减毒鼠伤寒沙门菌的应用.pdfVIP

第21卷 第3期 生命科学 Vol. 21, No. 3 2009年6月 Chinese Bulletin of Life Sciences Jun., 2009 文章编号 ：1004-0374(2009)03-0452-04 · 技术与应用 · 肿瘤生物治疗的新方法——减毒鼠伤寒沙门菌的应用 冉　茜，胡昌华 * (西南大学药学院，重庆 400715) 摘　要：减毒鼠伤寒沙门菌由于具有肿瘤靶向性，能在肿瘤组织中复制并产生抗肿瘤效果的能力，使 肿瘤治疗获得了新契机。减毒鼠伤寒沙门菌作为细菌载体使目的基因在肿瘤组织内特异表达，表现出良 好治疗效果。近期研究发现，单独使用突变后的菌株A1-R 在裸鼠模型上治疗乳腺癌和前列腺癌分别可 达到40% 和50% 的治愈率；在小鼠肿瘤转移模型中也展现出良好的治疗效果。鼠伤寒沙门菌作为肿瘤 治疗制剂有诱人的前景。本文就这些研究的最新进展做一综述。 关键词：减毒鼠伤寒沙门菌；活载体疫苗；基因治疗；细菌疗法 中图分类号：Q813; R691　　文献标识码：A New approach of biotherapy for cancer–application of attenuated Salmonella typhimurium RAN Qian, HU Chang-hua* (School of Pharmaceutical Science, Southwest University, Chongqing 400715, China) Abstract: Considering its tumor targeting, replication in tumor tissues and anti-tumor effects, attenuated Salmonella typhimurium has offered a new approach to tumor therapy. As a anti-tumor bacteria vector , S. typhimurium made gene express specifically in tumor tissue which showed the optimistic curative effect. Recent research revealed that the cure rate of the breast and prostate cancer in athymic mouse were up to 40% or 50% when a mutant of S. typhimurium A1-R was treated alone. It also showed a satisfactory treatment effect in the mouse tumor metastasis model. S. typhimurium has been the hot pot in the tumor research in recent years for its attractive prospects in tumor therapy. This article mainly reviewed the recent progress of S. typhimurium in tumor biotherapy. Key words: attenuated Salmonella typhimurium; live vector vaccine; gene therapy; bacteria therapy 自20世纪40年代以来，人们陆续注意到一些