肿瘤发生过程中的代谢重编程.pdf

中国科技论文在线 肿瘤发生过程中的代谢重编程# 1 2 2 2* 易梅 ，向波，李小玲 ，李桂源 （1. 中南大学湘雅医院皮肤性病科； 5 2. 中南大学肿瘤研究所） 摘要：很早以前就发现肿瘤细胞存在能量代谢异常，表现为糖酵解过度活跃，而线粒体有氧 代谢削弱，被称为“Warburg effect”。最近的研究表明，肿瘤组织中的代谢异常远比我们之 前认识的要复杂。尽管存在旺盛的糖酵解，实际上肿瘤组织仍然保留线粒体有氧代谢。另一 10 方面，线粒体是肿瘤细胞合成代谢的主要场所之一。肿瘤组织还发现存在脂肪酸代谢、氨基 酸代谢异常。肿瘤发生过程中，整个代谢网络在瘤基因、抑瘤基因主导下发生重编程，营养 组织在代谢网络中的流向和流量被重新定义。肿瘤细胞代谢重编程的法则在于平衡细胞能量 需求和合成代谢，以利于生物大分子合成，达到细胞倍增。靶向细胞代谢酶的抗肿瘤治疗， 目的并不是干扰肿瘤细胞的能量供应，而是影响其合成代谢速率，从而抑制肿瘤的增殖。 15 关键词：代谢重编程；生物合成途径；合成代谢；肿瘤发生 中图分类号：R75 ，Q75 Metabolic reprogramming in cancer 1 2 2 2 YI Mei , XIANG Bo , LI Xiaoling , LI Guiyuan 20 (1. Department of Dermatology, Xiangya hospital of Central South University; 2. Cancer research institute of Central South University) Abstract: Despite seminal studies in the 1920s by Warburg showing a characteristic metabolic pattern for tumors, cancer bioenergetics has often been relegated to the backwaters of cancer biology. Recent studies have shown that metabolism in tumor tissue is more complicated than we 25 previously knew. Despite vigorous glycolysis, in fact ，the tumor tissue still retains mitochondrial aerobic metabolism. Mitochondria is one of the main sites of the biosynthesis process of tumor cells tumor. Recent stuies revealed that abnormal fatty acid metabolism, amino acid metabolism play key role in tumorigenesis. The metabolic network in tumor cells was reprogrammed which leading to nutrition flux reorganization and re-derection.