大豆低聚糖和低聚肽对高脂血症大鼠血管活性物质和血液流变学的影响.DOCVIP

临床医学论文-大豆低聚糖和低聚肽对高脂血症大鼠血管活性物质和血液流变学的影响 【摘要】? 目的探讨大豆低聚糖(SOS)和大豆低聚肽(SOP)对高脂血症大鼠血管活性物质和血液流变学的影响。 方法 60只健康成年SD大鼠随机分为5组：分别饲喂正常饲料（正常对照组，NCG），高脂饲料（高血脂模型组，HCG），高脂饲料+2%SOS(SOS组)、高脂饲料+3%SOP(SOP组)、高脂饲料+2%SOS+3%SOP(SOSP组)8周，测定大鼠血脂、血管活性物质PGI2、TXA2、NO和血液流变学指标。结果 各实验组均能显著降低高脂血症大鼠血清TC、TG、LDLC，升高HDLC，改善血脂水平。同时升高PGI2、NO，降低TXA2和TXA2/PGI2比值，还能降低血黏度和红细胞压积，并以复合干预组效果最佳。结论 SOS和SOP具有良好的调节血脂、影响血管活性物质生成和改善血液流变学的作用，以联合使用效果最为显著。 【关键词】? 大豆低聚糖 大豆低聚肽 高脂血症 血管活性物质 血液流变学　 ??? Effects of soy oligosaccharides and peptides on vasoactive substances and hemorheology in hyperlipidemia rats ??? Abstract: Objective To investigate effects of soy oligosaccharides(SOS) and soy peptides(SOP) on vasoactive substances and hemorheology in hyperlipidemia rats. Methods Sixty healthy SD rats were randomly divided into five groups: They were fed with normal diet (NCG group), highfatty diet (HCG group); HF diet + 2% SOS (SOS group); HF diet + 3% SOP (SOP group); HF diet + 2% SOS + 3% SOP (SOSP group) for 8 weeks. Plasma levels of PGI2，TXA2，NO were measured and the changes of hemorheology were observed. Results SOS and SOP were able to decrease serum levels of TG，TC and LDLC，while increase HDLC remarkably to modulate dyslipidemia；decrease the plasma content of TXA2，TXA2/ PGI2 ratio，blood viscosity and hematocrit，while increase plasma contents of PGI2 and NO significantly, especially their complex intervention. Conclusion SOS and SOP can regulate blood lipid metabolism and vasoactive substances, as well as improve hemorheology, which is more effective when both together. ??? Keywords：SOS; SOP; hyperlipidemia; vasoactive substances; hemorheology ??? 动脉粥样硬化（atherosclerosis，AS）是危害人类健康的常见疾病，研究表明，内皮细胞损伤和内皮功能紊乱参与了AS形成过程，因此，保护内皮细胞既是预防AS形成也是预防粥样斑块破裂的关键之一［1］。大豆低聚糖（soy oligosaccharides,SOS）和大豆低聚肽（soy oligopeptides,SOP）是近年从大豆中提取的两种生物活性物质［2，3］。SOS是存在于大豆中的可溶性糖分的总称，主要成分为水苏糖、棉子糖和蔗糖，而SOP是大豆蛋白经酶解而得的分子质量低于1 000的低分子肽。国内外学者研究发现SOS和SOP具有降血脂作用， 但有关SOS和SOP对血管活性物质和血液流变学的影响目前未见报道。本研究观察了大豆SOS和SOP对实验性高脂血症大鼠血管活性物质和血液流变学的影响，探讨其调节血脂及抗AS的可能机制。 ??