抑制素B水平及相关因素与卵巢反应性的探讨.DOCVIP

临床医学论文-抑制素B水平及相关因素与卵巢反应性的探讨 【摘要】? 目的： 探讨抑制素B(INHB)水平及相关因素与卵巢反应性的关系，寻求预测卵巢反应性的较好指标。方法: 收集55例首次接受体外受精/单精子卵胞浆内注射受精-胚胎移植术（IVF/ICSIET）治疗的患者，在上次月经周期的第2～4天及降调节后控制性卵巢刺激日分别取血测定INHB、卵泡刺激素(FSH)；根据获卵数、注射绒毛膜促性腺激素日雌激素水平、促性腺激素(Gn)用量，将患者分为低反应组、正常反应组、高反应组，比较3组降调节前后INHB及FSH水平、年龄(AGE)、窦卵泡数(antral follicles counts,AFC)、Gn用量、Gn起始剂量，分析卵巢反应性与这些指标的关系。结果: （1）降调节前后的INHB(bINHB、INHBd0)水平、AGE、AFC、Gn用量、Gn起始剂量在3组之间有统计学差异（P0.05），降调节前后的FSH（bFSH 、FSHd0）水平在3组间无统计学差异（P0.05）；（2）获卵数与降调节前后INHB水平、AGE和AFC无相关性，与降调节前后FSH水平呈负相关，降调节FSH水平较基础FSH水平更具统计学意义。结论: 降调节前后的INHB水平可能不是预测卵巢反应性的较好指标，降调节前后的FSH水平可能能较好的预测卵巢反应性，且降调节后的FSH水平可能较基础FSH水平更具有临床价值。 【关键词】? 抑制素类； 胚胎移植； 卵巢功能试验； 年龄因素； 卵泡 　　［Abstract］Objective: To explore the value of serum inhibin B (INHB) levels and other relevant factors in predicting ovarian response in in vitro fertilization/intracytoplasmic sperm injection fertilization and embryo transfer (IVF/ICSI～ET) cycles，and so as to find better indicators for ovarian response. Methods: A total of 55 patients undergoing IVF were chosen, and their serum INHB and folliclestimulating hormone (FSH) were detected on day 2～4 of the menstrual cycle and before the first administration of gonadtrophin after the downregulation. The number of retrieved oocytes (NRO) was calculated. According to NRO and the levels of estrogen (E2) on human chorionic gonadotropin (HCG) administration day, and the total gonadotropin (Gn)dosage used, patients were divided into 3 groups: low response, high response, and normal response. The serum levels of INHB, FSH, antral follicles counts (AFC), Gn dosages used, and the initial doses of Gn of these groups before and after the downregulation were determined. The data together with patients age were analyzed statistically with methods of correlation analysis and stepwise linear regression analysis. Results:(1) There were statistically significant differences of INHB levels, age, AFC, Gn dosages, initial doses of Gn before and after the downregulation among the 3 groups (P0.05), while no si