p53、survivin在足月胎盘的表达研究论文.pdfVIP

p53、survivin在正常足月胎盘的表达研究 摘要 目的：探讨足月妊娠分娩发动与胎盘组织中凋亡相关蒸因 p53、survivin表达的关系。方法：取正常足月孕妇胎盘组织 80铡(经黼道分娩40例作为研究组，未晒产行剖窘产40例 {乍必对照缀)，固定、程蟮包蠼、裂冀，应嬲免疫缀纯捡濑舔 究组与对照组胎盘组织中p53、survivin蛋白的表达。图象分 析系统测定胎盘滋养层阳性细胞的平均光密度以袭示两维胎 盘缝织中晌p53、survivin表达的情况。结果：研究组的胎盘 组织中p53、survivin熬平均毙密度均低予鼹照缝中(p 结论：胎盘组织中细胞凋亡可能参与诱导分娩的发作。survivin 基闵在胎淼组织中的凋亡可能楚菲p53依赖性的。 survivin 关键词：凋亡p53 分娩 the of andsurvivininthenormal A on expressionp53 Study term placenta Abstract the between objective：Toinvestigaterelationshipapoptosis associated andsurvivinandlaborinthenormalterm genep53 term 40 normal tissuesfrom placenta．Methods：Theplacental casesof with 40 delivery(study vaginal group)，and pregnancy withabdominal onsetwere cases delivery(controlgroup)before and immunohistoch— sectioned，finally fixed，paraffin—embedded stained．Positivecellsofthetwo in emically genesproteins term weredetermined through wophoblasts average placental microscopeimageanalysissystem．Resu— density(OD)by optical Its：The ofODofthetwo inthe genes study expression proteins was