POLFIRI方案联合复方苦参治疗晚期结直肠癌的临床观察.docVIP

POLFIRI方案联合复方苦参治疗晚期结直肠癌的临床观察 【摘要】目的 评估对晚期结肠癌应用POLFIRI方案联合复方苦参的疗效和耐受性。方法　应用POLFIRI方案对21例患者行化疗，全部采用复方苦参静滴，40天后评价副作用，观察疗效，肿瘤标记物CA72-4，CEA的变化。结果　疗效为PR 6例28.6%，CR 0例，PD 2例9.5%，SD 13例61.9%，毒副作用表现为腹痛，延迟性腹泻，4度为1例（4.8%），3度为两例（9.5%）。化疗后CEA,CA72-4下降(Plt;0.05)。结论　对晚期结直肠癌应用POLFIRI方案，同时联合复方苦参的治疗耐受性好，效果明显。 【关键词】肠癌　复方苦参　疗效 【Abstract】 Objective: To evaluate the effective and tolerance of treatment to advanced colon cancer with POLFIRI combined matrine. Methods: 21 patients treated with chemotherapy in POLFIRI, combined with matrine infusion, effective was observed after 40 days, toxicity was evaluated, tum