肿瘤血管正常化与肿瘤治疗.pdfVIP

肿瘤2013 年7 月第33 卷第7 期　TUM OR Vol. 33, J uly 2013　　 653 DOI: 10.3781/j .issn.1000-7431.2013.07.015 Copyright© 2013 by TUM OR Review 综述 · 肿瘤血管正常化与肿瘤治疗 汪思亮，盛晓波，韦忠红，杨召聪，陈　晨，陈文星，王爱云，郑仕中，陆　茵 南京中医药大学药学院江苏省药效与安全性评价重点实验室，江苏南京　2 10046 [ 摘要 ]　传统的抗血管生成疗法的目的在于阻断有助于肿瘤生长和转移的营养通道。虽然这类药物已在临床上应 用多年，但其治疗效果仍存在争议，并可能会进一步增加化疗药物耐药性的产生。造成这一现象的原因可能是由 于促血管生长因子的过度表达和释放，使得肿瘤组织血管呈现出一种结构和功能异常的状态。基于此，有学者提 出了肿瘤血管的正常化理论。诸多研究显示，肿瘤血管正常化可以作为抗肿瘤治疗的补充疗法。本文着重讨论肿 瘤血管正常化的分子机制、临床优势以及仍待解决的问题，以便为肿瘤研究工作者及正在研发肿瘤血管抑制剂的 制药企业提供有益的参考。 [ 关键词 ]　肿瘤；新生血管化，病理性；肿瘤辅助治疗；血管正常化 [中图分类号]　R730.5 [文献标志码] A [文章编号]　1000-7431 (2013) 07-0653-05 Tumor blood vessel normalization and antitumor therapy WANG Si-liang, SHENG Xiao-bo, WEI Zhong-hong, YANG Zhao-cong, CHEN Chen, CHEN Wen-xing, WANG Ai-yun, ZHENG Shi-zhong, LU Yin Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Traditional Chinese Medicine, Nanjing 210046, Jiangsu Province, China [A BSTRACT]　Traditional anti-angiogenesis strategies attempt to limit the blood supply to tumor and hence inhibit tumor growth. Although such therapeutic strategies have been used in clinical practice for many years, their effects are still controversial because they may lead to drug resistance. As a result of excessive production of angiogenic molecules, the tumor vessels become abnormal in structure and function. Based on these findings, some researchers have proposed a theory of normalization of tumor blood vessels. The evidence from preclinical and initial clinical trials revealed that normalization of tumor blood vessels could be considered as a complementary therapy to treat tumor. In this article, the mechanisms, benefits, and possible clinical translation