mTOR功能及其抑制剂研究进展_邹金凯.pdfVIP

2008 10 16 10 # 1793# mTOR功能及其抑制剂研究进展 邹金凯, 车 宁, 孙春华 The development of mTOR function and its inhibitors ZOU Jin- kai, CHE N in , SUN Chun- hua D ep arm ent of P harmacy, B e ij ing H osp ital of M in istry of P ublicH ealth, B e ij ing 100730, Ch ina. = A bstractM amm alian tar et of rapam ycin (mTOR) is a serine/threon ine protein k inase, wh ich play s an mi portant role in tumor cell row th and proliferation. The abnorm al activities of TOR si nalin pathw ays are ti htly related to tu- m ori enesis. mTOR is a potential therapeutic tar et. M any new mTOR inh ib itors have come intom arket. The structure, function, si nalin pathw ay and inh ib itors of mTOR are review ed in th is article. = K ey w ordsmTOR; si nalin pathw ay; mTOR inhib itors M odern Oncolo y 2008, 16( 10) : 1793- 1795 = ( m amm alian tar et of rapamy cin mTOR)/ , mTOR , mTOR , mTOR , mTOR mTOR mTOR =mTOR; ; mTOR = R730. 3 =A = 1672- 4992- ( 2008) 10- 1793- 03 1 m TOR mTOR mTOR ( m amm alian tar et of rapam y- , mTOR- Raptor cin, mTOR)/ , mTOR- R ichtormTOR - Rap tor ( phosphoinositide k inase- TOR Rap tor( re u latory associated pro- related k inase, PIKK), mTOR PI3K /PKB ( protein kinase B, tein of TOR), mLST 8( m ammalian ortholo of LST8) mTOR, PKB ) mTOR COG ( controller of row th, 1p36. 2, mTOR, COG ), LST8 TOR, Raptor mTOR , 289kDa, 2459, mTOR, Raptor, mTOR [ 1] , TOR TOS (TOR- si nallin motif, TOS) mTOR 20, 70S 6 S6K1( p70S6 k inase protein, S6K 1) 2 40 A , 4E - B